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Acoustic Neuromas: Subtotal Resection & Radiosurgery
The purpose of this study is to analyze the effectiveness of subtotal removal followed by radiosurgery compared to complete removal for patients with large acoustic neuromas.
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Gliadel Wafers & Permanent I-125 Seeds for Glioblastoma
The purpose of this study is to evaluate the use of combining chemotherapy wafers and radioactive seeds, placed directly into the tumor cavity, to treat glioblastoma multiforme (GBM) tumors. < more details >
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Comparison of Dura Sealants for Cranial Surgery
The purpose of this study is to compare a new FDA approved dura sealant to other methods or products for closing the dura and preventing CSF leaks after brain surgery.
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Hyperbaric Oxygen Therapy for Radiation Necrosis
The purpose of this study is to determine the effects of complementing steroid medication management with hyperbaric oxygen therapy (HBOT) in treating brain radiation necrosis. < more details >
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Biomarkers for Subarachnoid Induced Cerebral Vasospasm
The purpose of this study is to identify traits of a condition or disease called biomarkers that will enable a physician to predict if and when a patient will experience cerebral vasospasm (narrowing of the vessels that supply blood and oxygen) in the brain after aneurysmal subarachnoid hemorrhage.
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Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)
The purpose of the CREST study is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack) or a mild stroke. < more details >
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Carotid Occlusion Surgery Study (COSS)
The purpose is to determine if Extracranial-Intracranial Bypass can reduce the chance of a subsequent stroke in someone who has complete blockage in one main artery and has already suffered a small stroke. < more details >
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IVH Removal: Intraventricular rt-PA
This is a study to evaluate how recombinant tissue plasminogen activator (rt-PA) is utilized in patients with intraventricular hemorrhage (IVH). < more details >
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Familial Intracranial Aneurysm Study
The purpose of this study is to identify the genes that may be important in the development of intracranial aneurysms. < more details >
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ICH Removal: Minimally Invasive Surgery + rt-PA (MISTIE)
The purpose of this study is to evaluate the use of rt-PA (a clot-busting drug) after a surgical procedure to remove a blood clot from the brain after an intracerebral hemorrhage (ICH).
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Neuroform™ Stent for Wide-neck Aneurysms
The purpose of this study is to monitor the effectiveness of the Neuroform Stent in treating wide-neck aneurysms in the brain.
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Wingspan™ Stent for Blocked Brain Arteries
The purpose of this study is to monitor the effectiveness of the Wingspan Stent System to open arteries in the brain that have become blocked by a clot or narrowed by plaque.
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Duragen Plus to Minimize Adhesions after Lumbar Discectomy
The purpose of this study is to evaluate the safety and effectiveness of DuraGen Plus® as an adhesion barrier in spinal surgery to reduce the extent of scar tissue formation and pain in comparison to a control group receiving standard care.
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Prevention of Disability after Spinal Cord Injury
The purpose of this study is to determine the most effective dose of the drug Cethrin® to prevent cell death after a spinal cord injury.
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New Spinal Sealant for Dura Repair
The purpose of this study is to compare a new spinal sealant to traditional methods for closing the dura and preventing CSF leaks after surgery.
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Libra™ Deep Brain Stimulator for Parkinson's Disease
The purpose of this study is to determine whether the Libra™ deep brain stimulation (DBS) system can help reduce some of the symptoms of Parkinson's disease that are not adequately controlled with medication.
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Eon™ Spinal Cord Stimulator for Chronic Back & Leg Pain
The purpose of this study is to evaluate the effectiveness of the Eon™ spinal cord stimulator to manage chronic back and leg pain.
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Prevention of Seizures after Brain Injury
The purpose of this study is to compare the safety and effectiveness of two different medications, levetiracetam and phenytoin, as seizure prevention after traumatic brain injury or subarachnoid hemorrhage.
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Near-infrared Spectroscopy to Detect Bleeding in the Brain
The purpose of this trial is to gain information about an Infrascanner device. This device uses near-infrared spectroscopy (NIRS). NIRS is the measurement of the wavelength of the absorption of light and can be used to identify a compound and to investigate the composition of that compound. In this case, the compound is blood. The investigators are working with InfraScan, Inc. to conduct an observational research trial to find out more about how sensitive the Infrascanner is at detecting a hemorrhage or bleeding in the brain in patients who have suffered a traumatic brain injury (TBI).
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Recovery of Consciousness after Traumatic Brain Injury
The purpose of this study is to gain information about the chemicals related to coma after a traumatic brain injury (TBI) and the effectiveness of the drug amantadine as a therapy to treat coma.
