Active trials

1. Acoustic Neuromas: Subtotal Resection & Radiosurgery
   The purpose of this study is to analyze the effectiveness of subtotal removal followed by radiosurgery compared to complete removal for patients with large acoustic neuromas.

2. Carotid Occlusion Surgery Study (COSS)
   The purpose is to determine if Extracranial-Intracranial Bypass can reduce the chance of a subsequent stroke in someone who has complete blockage in one main artery and has already suffered a small stroke. < more details >

3. Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON)
   The purpose of this study is to determine the relationship between mental functioning and blood flow in the brain among patients that have already consented to participate in the Carotid Occlusion Surgery Study (COSS)

4. Familial Intracranial Aneurysm Study
   The purpose of this study is to identify the genes that may be important in the development of intracranial aneurysms. < more details >

5. ICH Removal: Minimally Invasive Surgery + rt-PA (MISTIE)
   The purpose of this study is to evaluate the use of rt-PA (a clot-busting drug) after a surgical procedure to remove a blood clot from the brain after an intracerebral hemorrhage (ICH).

6. Clazosentan in Aneurysmal Subarachnoid Hemorrhage (CONSCIOUS-2)
   The purpose of this research study is to evaluate whether the research drug can reduce the risk of developing vasospasm after subarachnoid hemorrhage and determine the side effects associated with the research study drug (clazosentan).

7. Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS)
   The purpose of Phase 1 of the research study is to see whether intensive medical therapy only or intensive medical therapy plus angioplasty and stenting will have the most success in preventing patients with a narrowed brain artery from having a stroke. The purpose of phase 2 is to get more information on how the stent works over a longer period of time after being used to treat patients with a narrowed brain artery.

8. Neuroform™ Stent for Wide-neck Aneurysms
   The purpose of this study is to monitor the effectiveness of the Neuroform Stent in treating wide-neck aneurysms in the brain.

9. Wingspan™ Stent for Blocked Brain Arteries
   The purpose of this study is to monitor the effectiveness of the Wingspan Stent System to open arteries in the brain that have become blocked by a clot or narrowed by plaque.

10. CORDIS ENTERPRISE™ Vascular Reconstruction Device & Delivery System
    The purpose of this study is to monitor the effectiveness of the Cordis Enterprise Device in treating aneurysms in the brain.

11. Onyx Liquid Embolic System HD-500
    The purpose of this study is to monitor the effectiveness of the Onyx Liquid Embolic System in treating aneurysms in the brain.

12. INFUSE® Bone Graft for Spine Fusion
    The purpose of this study is to determine the safety and effectiveness of a polymer implant (PEEK cage) and bone morphogenetic proteins (BMP) to create a spinal fusion in the neck (cervical) area of the spine. Fusion is the joining together of two separate bones into one and is a treatment option for cervical degenerative disc disease.

13. Duragen Plus to Minimize Adhesions after Lumbar Discectomy
    The purpose of this study is to evaluate the safety and effectiveness of DuraGen Plus® as an adhesion barrier in spinal surgery to reduce the extent of scar tissue formation and pain in comparison to a control group receiving standard care.

14. Libra™ Deep Brain Stimulator for Parkinson's Disease
    The purpose of this study is to determine whether the Libra™ deep brain stimulation (DBS) system can help reduce some of the symptoms of Parkinson's disease that are not adequately controlled with medication.

15. Target Imaging for Assistance in Treatment of Parkinson's
    The purpose of this study is to determine whether sophisticated new imaging technologies can help pinpoint placement of deep brain stimulation electrodes in patients with Parkinson's Disease.

16. Spreading Depression
    The purpose of this study is to examine a form of brain seizure activity and its impact on recovery from brain injury.
    

Closed trials in follow-up

• Gliadel Wafers & Permanent I-125 Seeds for Glioblastoma
  

• Biomarkers for Subarachnoid Induced Cerebral Vasospasm
  

• IVH Removal: Intraventricular rt-PA
  

• Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)
  

• Comparison of Dura Sealants for Cranial Surgery
  

• New Spinal Sealant for Dura Repair

• Eon™ Spinal Cord Stimulator for Chronic Back & Leg Pain

• Prevention of Disability after Spinal Cord Injury
• Prevention of Seizures after Brain Injury
• Near-infrared Spectroscopy to Detect Bleeding in the Brain
• Recovery of Consciousness after Traumatic Brain Injury
• Cortical Stimulation in Treatment of Upper Extremity Hemiparesis
  
• Assessment of Surgery for Cervical Spondylotic Myelopathy
• Lumbar stabilization using the AxiaLif system
• Evaluation of the PathFinder™ System for Pedicle Screw Insertion
• Evaluation of the CODA Expandable Fusion Cage
• FlexiCore™ Artificial Disc for the Treatment of Discogenic Pain
• ChillerStrip™ Hypothermia System for Aneurysm Surgery
• Safety and Tolerability of DTI-015 in Patients with Recurrent Glioblastoma Multiforme
• Hemicraniectomy and Durotomy Upon Deterioration from Infarction Related Swelling (HeADDFIRST)
• Evaluation of ForSite Device to Measure Pupillary Size
• National Acute Brain Injury Study: Hypothermia II
• Prevention of Vasospasm & New Infarction after Aneurysmal SAH Following Administration of Clazosentan
• Evaluation of a Single IV Dose of Dexanabinol in Patients Suffering from Severe TBI
• Procrit® (Epoetin Alfa) Administered Perioperatively Versus Standard of Care in Blood Conservation in Subjects Undergoing Major Elective Spinal Surgery
• DuraSeal™ System as an Adjunct to Sutured Dural Repair During Cranial Surgery